Systemic effects of medications used to treat glaucoma. Via this pharmacological effect, anagrelide induces high-output HF.182 The effect appears to be dose related and may occur days to years after the drug is initiated, although a temporal association with a dose increase is often reported. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. The risk of new onset heart failure associated with dopamine agonist use in Parkinson’s disease. Myocardial protection with volatile anaesthetic agents during coronary artery bypass surgery: a meta-analysis. Atrioventricular dissociation in a patient receiving clonidine. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Valvular regurgitation occurred in 12% of patients treated for >90 days compared with 5.9% of unexposed patients (OR, 2.2; 95% CI, 1.7–2.7). Effect of dronedarone on cardiovascular events in atrial fibrillation [published correction appears in. A review of 3689 patients who received lapatinib in 44 phase I to III trials revealed a 0.2% rate of symptomatic HF and 1.4% rate of asymptomatic cardiac events.149 Prior exposure to trastuzumab and anthracyclines was associated with an increased incidence of adverse cardiac events, on the order of 2.2% and 1.7%, respectively. Mechanism of decongestant activity of alpha 2-adrenoceptor agonists. Understanding NSAIDs: from aspirin to COX-2. Although data in patients with HF are limited to case reports, the FDA suggests caution be taken when using pregabalin in patients with NYHA class III to IV HF, especially in combination with thiazolidinediones, due to possible development of peripheral edema and HF exacerbation.203, Several of the antipsychotic medications, both typical and atypical, have been associated with numerous cardiovascular side effects consisting of significant dose-related sudden cardiac death, cardiac arrhythmias, in particular TdP secondary to the corrected QT interval (QTc) prolongation, tachycardia, and orthostatic hypotension.204–207 Myocarditis and cardiomyopathy are rare but potentially fatal complications of antipsychotic therapy. High-dose ifosfamide is associated with severe, reversible cardiac dysfunction. Polypharmacy is a significant concern in patients with HF because of the burden of both cardiovascular and noncardiovascular conditions. Stadtausgabe (Lokalteil Stuttgart Innenstadt) Stadtausgabe (Lokalteil Stuttgart Innenstadt) Alle Lokalausgaben Blick vom Fernsehturm Fellbach und Rems-Murr-Kreis Filder-Zeitung Leinfelden/Echterdingen Filder-Zeitung Vaihingen/Möhringen Kornwestheim und Kreis Ludwigsburg Kreisausgabe Böblingen Kreisausgabe Esslingen Kreisausgabe Göppingen … The biological mechanisms of cardiotoxicity are under active investigation. Early recognition of clozapine-induced myocarditis. Cardiac dysfunction in the trastuzumab clinical trials experience. The current standard for cardiac monitoring in patients receiving an anthracycline is LVEF assessment. Cyclophosphamide exerts antitumor effects by DNA cross-linking and inhibition of DNA synthesis.118 Cyclophosphamide is a prodrug that requires hepatic conversion to its active phosphoramide mustard via cytochrome P450 enzymes. Long-term prognosis after peri-operative cardiac complications. Rare cases of valvulopathy and pulmonary hypertension have been submitted to the FDA in patients who reportedly took phentermine alone.248 Another appetite suppressant, sibutramine, was withdrawn from the market for increased risk of nonfatal MI and stroke.249. Risk factors for doxorubicin-induced congestive heart failure. Dipeptidyl peptidase-4 inhibitors and heart failure: a meta-analysis of randomized clinical trials. Of note, the majority of patients were receiving tamsulosin (58%). Acute cardiotoxicity manifests within days of administration and most commonly includes rhythm abnormalities (arrhythmias) but also electrocardiographic changes, tachycardia, and pericarditis/myocarditis. It has never been directly studied in patients with HF; however, the increased risk is presumed to occur within 1 month of initiation because of the nature of the observed electrophysiological effects and extrapolation from the effects of oral milrinone, a pharmacologically similar medication.186, It is known that cilostazol produces a dose-related increase in heart rate of 5 to 7 bpm and a higher rate of ventricular premature beats and nonsustained ventricular tachycardia, regardless of dose received. High-dose itraconazole in the treatment of severe mycoses. Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure. Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart failure. In response to growing case reports, a retrospective chart review of 3491 patients identified a clear cumulative increase in the risk of developing HF with increasing doses of doxorubicin, expressly at total doses >550 mg/m2, thereby suggesting the theoretical cumulative dose limit that is often used clinically today to minimize the risk of A-HF. Immediate: Effect is demonstrated within 1 wk of drug administration. On repeat assessment of cardiac function after 3 weeks, there was some degree of LVEF recovery in all participants, as defined by an LVEF that was either >45% or 40% to 45% and <10% from baseline. A case of pregabalin-associated heart failure decompensation in a patient with a history of stage I heart failure. CAMs With Significant Interactions With Cardiovascular Medications Used in Patients With HF320. Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? This impairs intracellular degradation and leads to accumulation of pathological metabolic products such as phospholipid and glycogen.279,280 On histology, these appear as granulovacular cell mutations and ultrastructurally as lamellar membranous inclusion bodies and curvilinear bodies in the cytoplasm. Get the latest news and analysis in the stock market today, including national and world stock market news, business news, financial news and more Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers. Appetite-suppressant drugs and the risk of primary pulmonary hypertension: International Primary Pulmonary Hypertension Study Group. The VEGF receptors are clearly important in mediating the ventricular remodeling response to increased afterload, as indicated by basic science studies.162 Additional studies suggest that inhibition of AMP-kinase activity and the inositol-requiring enzyme stress response by sunitinib may play a critical role in mediating cardiac dysfunction.157,163 Sunitinib is believed to compete with adenosine triphosphate for binding to AMP-kinase, thereby preventing its activity and exacerbating energy depletion under states of increased cardiomyocytes stress. Respiratory illness, beta-agonists, and risk of idiopathic dilated cardiomyopathy: the Washington, DC, Dilated Cardiomyopathy Study. (as per respective below tagged Districts. Novel approaches to identify patients with anthracycline-induced cardiotoxicity earlier in their treatment paradigm include the use of biomarkers. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Development of heart valve lesions during methysergide therapy. In the RENAISSANCE (Randomized Etanercept North American Strategy to Study Antagonism of Cytokines) and RECOVER (Research into Etanercept Cytokine Antagonism in Ventricular Dysfunction) trials, etanercept had no impact on the clinical status in patients with NYHA class II, III, or IV HF compared with control subjects.274 In the ATTACH trial (Anti-TNF Alpha Therapy Against CHF), higher rates of HF-related hospitalization or death were noted in the patients with NHYA class III or IV HF receiving infliximab 10 mg/kg compared with the 5-mg/kg dose (HR, 2.84; 95% CI, 1.01–7.97).275 However, a recent systematic review in patients with rheumatoid arthritis and HF that included observational studies and a meta-analysis found no increase in the risk of incident or worsening HF in patients treated with tumor necrosis factor-α inhibitors (infliximab, etanercept, and adalimumab) except for patients ≥65 years of age, who had a higher risk of HF hospitalization (HR, 1.7; 95% CI, 1.07–2.69) and death (HR, 4.19; 95% CI, 1.48–11.89).276 The 2015 American College of Rheumatology treatment guidelines for rheumatoid arthritis recommend that a tumor necrosis factor-α inhibitor should only be considered in patients with HF if there are no other reasonable treatment options, and then consider only in patients with compensated HF.277, Hydroxychloroquine is an antimalarial that has become a mainstay in the management of systemic lupus erythematosus and rheumatoid arthritis. Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (Prospective Randomized Amlodipine Survival Evaluation 2). Effects of flecainide on ventricular function: clinical and experimental correlations. It is reasonable to establish a team management approach in which a healthcare provider acts as “captain” of the medications and instructs patients to notify this individual whenever a medication is changed or added to the medication list. The latest news and headlines from Yahoo! Overall, cardiotoxicity is more common (up to 18%) with intravenous 5-FU compared with oral capecitabine (1.9%–3.7%).129,130 Although the exact incidence is unknown, a growing number of case reports recognize cardiomyopathy and acute decreases in LVEF with 5-FU treatment.131–133 Apical ballooning, commonly seen in Takotsubo cardiomyopathy, has been reported on numerous occasions. 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